Effects of Amlodipine,Captopril, and Bezafibrate on Oxidative Milieu in Rats with Fatty Liver |
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Authors: | Zvi Ackerman Mor Oron-Herman Talma Rosenthal Orit Pappo Gabriela Link Ben-Ami Sela Maria Grozovski |
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Affiliation: | (1) Department of Medicine, Hadassah-Hebrew University Medical Center, Mount Scopus Campus, P.O. Box 24035, Jerusalem, 91240, Israel;(2) Hebrew University Medical School, Jerusalem, Israel;(3) Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel;(4) Institute of Chemical Pathology, Sheba Medical Center, Tel Hashomer, Israel;(5) Department of Pathology, Hadassah-Hebrew University Medical Center, Mount Scopus Campus, P.O. Box 24035, Jerusalem, 91240, Israel;(6) Department of Human Nutrition and Metabolism, Hebrew University Medical School, Jerusalem, Israel;(7) Ort Braude College of Engineering, Karmiel, Israel |
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Abstract: | Oxidative stress may initiate significant hepatocyte injury in subjects with fatty liver. We characterized changes in hepatic oxidative anti-oxidative parameters in rats given a fructose-enriched diet (FED) with and without medications to reduce blood pressure or plasma triglycerides. FED rats had an increase in malondialdehyde (MDA) concentration, a reduction in α-tocopherol concentration, a reduction in paraoxonase (PON) activity, an increase in glutathione peroxidase (GSH-Px), and glutathione reductase (GSSG-R) activity. Amlodipine increased PON and GSH-Px, but decreased GSSG-R activity and α-tocopherol concentration. Captopril decreased MDA concentration and the activity of both GSH-Px and GSSG-R, but increased α-tocopherol concentration and PON activity. Bezafibrate increased α-tocopherol concentration and PON activity, but decreased the activity of GSSG-R. Animals with fatty liver exhibit an increase in peroxidative stress but also a defect in anti-oxidative pathways. Drugs administered to treat hypertension and hypertriglyceridemia could lead to a variety of changes in the hepatic oxidative, anti-oxidative milieu. |
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Keywords: | Malondialdehyde Alpha-tocopherol Paraoxonase Glutathione peroxidase and reductase Amlodipine Captopril Bezafibrate |
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