番茄红素对EC-9706细胞增殖及细胞周期的影响

目的：研究番茄红素对人食管癌细胞EC-9706的增殖及细胞周期的影响。方法：MTT法检测番茄红素对EC-9706增殖的抑制作用，采用流式细胞仪检测同步化的细胞经番茄红素作用后细胞周期和凋亡的变化。结果：番茄红素能够明显抑制EC-9706细胞的生长，呈现时间和剂量依赖性；且诱导细胞凋亡；并阻滞细胞周期于S期。结论：番茄红素可抑制EC-9706细胞的增殖，其机制可能为诱导细胞凋亡和改变细胞周期。

Effect of Lycopene on Proliferation and Cell Cycle of EC-9706 Cell Line

Objective： To investigate the effect of lyeopene on proliferation and ceil cycle of EC-9706. Method： After treated with lyeopene,The proliferation of EC-9706 cells were detected by MTT assay. Cell cycle and apoptosis was detected by flow cytometry. Resuit： Lycopene resulted in significant inhibition of EC-9706 cells in a dose-dependent manner. Flow cytometry assay suggested that lycopene could changed the cell cycle distribution and induced apoptosis. Conclusion： Lycopene can inhibit the proliferation of EC-9706 cells effectively, cause the change of cell cycle and EC-9706 cells apoptosis appeared.