| 透明质酸酶诱导兔颞下颌关节骨关节病的实验研究 |
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| 引用本文： | 陈慧芝 陈欣然. 透明质酸酶诱导兔颞下颌关节骨关节病的实验研究[J]. 北京口腔医学, 1999, 7(1): 7-9 |
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| 作者姓名： | 陈慧芝 陈欣然 |
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| 作者单位： | 广州市红十字会医院口腔科 |
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| 摘 要： | 目的：建立兔颞下颌关节骨关节病动物模型。方法：将不同浓度透明质酸酶（ＨＤ）一次性注入两组兔颞下颌关节下腔内，分别于注射后２４ｈ、１、４、８、１２周后处死动物，对颞下颌关节标本进行组织学观察。结果：注射ＨＤ４周后出现关节软骨破坏，关节盘腔原纤维暴露，滑膜慢性炎症等骨关节病表现。结论：本实验研究建立了颞下颌关节骨关节病模型可用于颞与颌关节骨关节病早、中期病变的研究 。
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| 关 键 词： | 颞下颌关节疾病 骨关节病 透明质酸酶 动物模型 |
OSTEOARTHROSIS OF THE TEMPOROMANDIBULAR JOJNT INDUCED BY HYALURONIDASE IN ADULT RABBITS |
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| Chen Huizhi,et al.. OSTEOARTHROSIS OF THE TEMPOROMANDIBULAR JOJNT INDUCED BY HYALURONIDASE IN ADULT RABBITS[J]. Beijing Journal Of Stomatology, 1999, 7(1): 7-9 |
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| Authors: | Chen Huizhi et al. |
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| Affiliation: | Chen Huizhi,et al.Guangzhou Red Cross Hospital,Guangzhou,510220 |
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| Abstract: | Objective:To establish an animal of osteoarthrosis(OA) in the temporomandibular joint(TMJ) (TMJOA) by injecting hyaluronidase(HD)into the downer compartments of TMJs in adult rabbits.Methods:Adult rabbits were randomly divided into four groups of five animals each.C and D groups were used as control.In group A and group B HD was injected into the downer compartments at two different concentrations at a volume of 0.1ml.The samples of TMJs were analyzed histologically in four different times after injection.Results:The animals which had injected HD at different concentrations resulted in similar consequence.The typical changes of OA occurred in TMJ The damages were in early to moderate stage.No pathological changes could be found in TMJs of the control groups.Conclusion:The results suggest that HD may be of use in establishing the animal model of TMJOA. |
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| Keywords: | Temporomandibular joint(TMJ) Osteoarthrosis(OA) Hyaluronidase(HD) Animal model |
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