Adduct formation on DNA and haemoglobin in mice intraperitoneally administered with styrene期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Adduct formation on DNA and haemoglobin in mice intraperitoneally administered with styrene

Authors:	Pauwels, Wim Vodi{caron}cCeka, Pavel Severi, Mario Plna, Kamila Veulemans, Hendrik Hemminki, Kari

Affiliation:	¹Laboratory for Occupational Hygiene and Toxicology, Katholieke Universiteit Leuven Belgium ²Department of Developmental Genotoxicology, Institute of Experimental Medicine, Czech Academy of Sciences Vìdeò $"n"$ ské 1083, 14220 Prague 4, Czech Republic ³Karolinska Institute, CNT, NOVUM, Halsoväagen 7 Huddinge, Sweden

Abstract:	Styrene-specific N-7- and O⁶guanine DNA adducts and N-terminalvaline adducts were determined in mice tissues after the intraperitonealadministration of styrene. Blood, liver, lungs and spleen werecollected 3 h after administration of various doses (from 0to 435 mmol/kg b.w.) of styrene. DNA adducts were analysed bythe modified ³²P-postlabelling assay and N-terminal valine adductswere detected by GC-MS according to the modified Edman degradationtechnique. In the dose-range studied, for all adducts a cleardose-response relationship was observed. 7-Alkylguanines andO⁶-styrene guanine adducts were most abundant in lungs,

Keywords:
本文献已被 Oxford 等数据库收录！