| P-选择素和白介素-18在冠状动脉粥样斑块中相关表达 |
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| 引用本文： | 刘娟,魏俊香,陈丽琴.P-选择素和白介素-18在冠状动脉粥样斑块中相关表达[J].心脏杂志,2010,22(2):220-221. |
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| 作者姓名： | 刘娟 魏俊香 陈丽琴 |
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| 作者单位： | 内蒙古医学院:1.附属人民医院心内科，3.法医学系法医病理教研室，内蒙古
呼和浩特 010050；2.内蒙古妇幼保健医院内科，内蒙古 呼和浩特 010050 |
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| 摘 要： | 目的: 检测P-选择素（CD62P）和白介素-18（IL-18）在冠状动脉粥样硬化斑块中的表达水平，探讨CD62P和IL-18二者之间的相关性，为临床防治斑块形成和发展提供理论依据。方法: 选取65例尸检有粥样硬化的冠状动脉组织蜡块标本，采用免疫组化和图像分析技术检测冠脉中CD62P和IL-18的表达水平。结果: CD62P表达在冠状动脉血管内皮细胞膜上，表达水平增高时，粥样硬化斑块内巨噬细胞增多；IL-18主要表达在巨噬细胞胞浆中，CD62P表达增高时，IL-18表达也增高，二者表达具有相关性，并呈正相关关系(r=0.81，P<0.01)。结论: CD62P和IL-18在冠状动脉粥样硬化斑块中的表达具有相关性并呈正相关关系，提示二者可能在冠状动脉粥样斑块的形成和发展过程中是互相关联的炎症因子。
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| 关 键 词： | 冠状动脉粥样硬化斑块 P-选择素 白介素-18 |
| 收稿时间： | 2008-12-29 |
Correlative expression of P-selectin and IL-18 in human coronary atherosclerosis plaque |
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| LIU Juan,WEI Jun-xiang,CHEN Li-qin.Correlative expression of P-selectin and IL-18 in human coronary atherosclerosis plaque[J].Chinese Heart Journal,2010,22(2):220-221. |
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| Authors: | LIU Juan WEI Jun-xiang CHEN Li-qin |
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| Institution: | LIU Juan1,WEI Jun-xiang2,CHEN Li-qin3(1.Department of Cardiology,Affiliated Renming Hospital,3.Department of Forensic Pathology,faculty of Forensic Medicine,Inner Mongolia Medical College,Hohhot 010050,Inner Mongolia,China,2.Department of Internal Medicine,Healthcare Hospital of Women,China) |
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| Abstract: | AIM: To evaluate the expression level and the relationship of P-selectin(CD62P) and interleukin-18(IL-18) in human coronary atherosclerosis so as to provide theoretical evidence for clinical prevention and treatment of plaques.METHODS: Sixty five autopsy paraffin samples with coronary atherosclerosis were selected.The expression level of CD62P and IL-18 in the plaque of human coronary atherosclerosis was measured by immunohistochemical technique and image processing system.Data were analyzed statistically w... |
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| Keywords: | coronary atherosclerosis plaques P-selectin interleukin-18 |
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