奎硫平与利培酮治疗老年精神分裂症对照研究

目的探讨奎硫平与利培酮治疗老年精神分裂症的临床疗效及安全性。方法将60例老年精神分裂症患者随机分为两组各30例，研究组口服奎硫平治疗，对照组口服利培酮治疗，观察8w。于治疗前及治疗1w、2w、4w、8w末采用阳性与阴性症状量表评定临床疗效，副反应量表评定不良反应。结果治疗8w末，研究组显效率为83．3％、总有效率为93．3％；对照组分别为86．7％、93．3％，两组总体疗效相当（P〉0．05）。两组治疗第1w末起阳性与阴性症状量表总分及各因子分较治疗前均明显下降，不良反应程度均较轻微，但研究组总不良反应发生率显著少于对照组（P〈0．05），尤其是锥体外系反应及体重增加等明显少于对照组（P〈0．05），而直立性低血压和心电图改变发生率明显高于对照组（P〈0．05）。结论奎硫平与利培酮治疗老年精神分裂症的疗效显著且相当，不良反应均轻微，但表现形式有所不同。

A control study of quetiapine vs risperidone in senile schizophrenia

Objective To explore the clinical efficacy and safety of quetiapine vs risperidone in the treatment of senile schizophrenia. Methods 63 senile schizophrenics were randomly divided into two groups of 30 patients each, research group took orally quetiapine and control group did risperidone for 8 weeks. The clinical efficies were assessed with the Positive and Negative Syndrome Scale （PANSS） and adverse reactions with the Treatment Emergent Symptom Scale（TESS） before treatment and at the end of the 1^st , 2^nd , 4^th and 8^th week. Results At the end of the 8th week, obvious and total effective rate were 83.35% and 93.35 in the research and 86.7% and 93.3G in the control group, respectively, the general efficacy of the 2 groups was equivalent（P〉0.05）. Since the end of the 1st week, total and all factors scores of the PANSS of both groups lowered more significantly compared with pretreatment, adverse reactions of both groups were mild, but incidences of adverse reactions were significantly lower in the research than in the control group（P〈0.05）, especially extrapyramidal system raections and weight increase（P〈0.05） ; the incidences of orthostatic hypotension and ECG changes were significantly higher in the research than in the control group（P〈0.05）. Conclusion Quetiapine and risperidone have equivalent evident effects and mild adverse reactions in the treatment of senile schizophrenia, but patterns of manifestation are different.