胃苏颗粒联合四联疗法治疗Hp相关性消化性溃疡的临床观察

目的:探究胃苏颗粒联合四联疗法治疗幽门螺杆菌(Hp)相关性消化性溃疡(PU)的临床效果及对炎性反应递质水平的影响。方法:选取2016年7月至2018年4月广州市番禺区中心医院治疗的Hp相关性PU患者250例,按照随机数字表法将其分为对照组和观察组,每组125例。对照组给予四联疗法,观察组在此基础上给予胃苏颗粒治疗,统计2组患者治疗后的临床疗效、Hp根除率、溃疡愈合率、1年内复发率及不良反应发生率,比较2组患者治疗前后炎性反应递质的差异。结果:治疗后,观察组与对照组的临床治疗有效率分别为92. 00%、83. 23%,差异有统计学意义(P 0. 05);与治疗前比较,治疗后2组患者超敏C反应蛋白(hs-CRP)、降钙素原(PCT)显著降低,且观察组显著低于对照组,差异有统计学意义(P 0. 05);治疗后观察组与对照组的Hp根除率分别为92. 00%、83. 20%,溃疡愈合率分别为84. 00%、73. 60%,观察组高于对照组,差异有统计学意义(P 0. 05),1年内复发率分别为12. 80%、23. 20%,观察组显著低于对照组,差异有统计学意义(P 0. 05);观察组与对照组的不良反应发生率分别为16. 80%、27. 20%,观察组显著低于对照组,差异有统计学意义(P 0. 05)。结论:胃苏颗粒联合四联疗法治疗Hp相关性PU可以有效缓解临床症状,降低炎性反应递质水平,优于单纯西医治疗。

Clinical Observation on Weisu Granules Combined with Quadruple Therapy in the Treatment of Hp-related Peptic Ulcer

To explore the clinical effect of Weisu Granules combined with quadruple therapy in the treatment of Helicobacter pylori(Hp)-related peptic ulcer(PU)and its influence on the level of inflammatory factors.Methods:A total of 250 cases of Hp-related PU patients treated in our hospital from July 2016 to April 2018 were divided into a control group(n=125)and an observation group(n=125)according to random number table method.The control group was given quadruple therapy,and the observation group was given Weisu Granules treatment on this basis.The clinical efficacy,Hp eradication rate,ulcer healing rate,recurrence rate within one year and adverse reaction rate of the 2 groups after treatment were counted of 2 groups,and the differences of inflammatory factor levels between the 2 groups before and after treatment were compared.Results:After treatment,the total clinical effective rates of the observation group and the control group were 92.00% and 83.23%.The observation group was significantly higher than the control group(P<0.05); Compared with before treatment,the levels of hs-CRP and PCT in the two groups were remarkably lower after treatment,and those in the observation group were significantly lower than those in the control group(P<0.01).After treatment,the eradication rates of HP in the observation group and the control group were 92.00% and 83.20%,the healing rates of ulcers were 84.00% and 73.60%.The observation group was higher than the control group(P<0.05).The recurrence rates of 1 year in the observation group were 12.80% and 23.20% respectively,which were prominently higher than those in the control group(P<0.05),and the recurrence rates in the observation group were apparently lower than those in the control group(P<0.05).The incidence of adverse reactions in the observation group and the control group were 16.80% and 27.20%.The incidence of adverse reactions in the observation group was remarkably lower than that in the control group(P<0.05).Conclusion:Weisu Granules combined with quadruple therapy for Hp-related PU can effectively alleviate clinical symptoms and reduce the level of inflammatory factors,which is better than western medicine alone,and is worthy of clinical promotion and application.