丹参川芎嗪注射液治疗脑血栓患者的临床疗效及SOD、MDA、LPA和内皮素的作用分析

目的:研究丹参川芎嗪注射液治疗脑血栓患者的临床疗效及对超氧化物歧化酶(SOD)、丙二醛(MDA)、溶血磷脂酸(LPA)及内皮素(ET-1)的影响。方法:选取2015年3月至2018年2月解放军281医院收治的脑血栓患者78例作为研究对象,按照随机数字表法分为对照组和观察组,每组39例。对照组接受常规西药治疗,观察组采用丹参川芎嗪注射液联合常规西药治疗。观察治疗效果、功能评分及血清SOD、MDA、LPA、ET-1的含量。结果:观察组的整体疗效优于对照组(P 0. 05);治疗后7 d时,2组的中风临床症状评分、中医证候评分、美国国立卫生研究院卒中量表(NIHSS)评分及血清MDA、LPA、ET-1含量均明显降低,血清SOD含量均明显升高(P 0. 05)且观察组的中风临床症状评分、中医证候评分、NIHSS评分及血清MDA、LPA、ET-1含量均明显低于对照组,血清SOD含量均明显高于对照组(P 0. 05)。结论:丹参川芎嗪注射液治疗脑血栓能够改进疗效、改善症状并减轻氧化应激。

Clinical Efficacy of Danshen Chuanxiongqin Injection in Patients with Cerebral Thrombosis and Analysis on Its Effects on SOD, MDA, LPA and ET

To study the clinical efficacy of Danshen Chuanxiongqin Injection in patients with cerebral thrombosis and its effects on the content of superoxide dismutase(SOD), malondialdehyde(MDA), lysophosphatidic acid(LPA)and endothelin(ET-1).Methods:A total of 78 patients with cerebral thrombosis admitted in the People''s Liberation Army 281 Hospital during March 2015 to February 2018 were selected and randomly divided into a control group(n=39, routine western medicine treatment)and an observation group(n=39, routine western medicine treatment combind with Danshen Chuanxiongqin Injection).Therapeutic effect, functional score, and the content of serum SOD, MDA, LPA and ET-1 were observed.Results:The overall efficacy in the observation group was better than that in the control group(P<0.05); 7 days after the treatment, the clinical symptom scores of stroke, TCM syndrome scores, NIHSS scores and serum content of MDA, LPA, and ET-1 in the 2 groups were significantly decreased, and the serum SOD content was significantly increased(P<0.05).The clinical symptom score of stroke, TCM syndrome scores, NIHSS score and serum content of MDA, LPA and ET-1 in the observation group were significantly lower than those in the control group, and the serum SOD content was significantly higher than that in the control group(P<0.05).Conclusion:Danshen Chuanxiongqin Injection in the treatment of cerebral thrombosis can improve the efficacy, improve symptoms and relieve oxidative stress.