小柴胡汤合宣肺降火汤治疗喉源性咳嗽的疗效观察

目的:探讨小柴胡汤合宣肺降火汤治疗喉源性咳嗽的效果及对患者免疫功能、气道阻力的影响。方法:选取2015年11月至2017年4月都江堰市人民医院收治的喉源性咳嗽患者108例作为研究对象,根据治疗药物不同将患者分为对照组(n=49)和观察组(n=59),对照组给予常规西药治疗,观察组采用小柴胡汤合宣肺降火汤治疗,2组均连续治疗14 d。比较治疗后临床疗效及主要临床症状改善情况,比较治疗前后2组患者T淋巴细胞亚群比例、免疫球蛋白水平及气道阻力变化。结果:治疗后观察组治疗有效率为96. 61%,明显高于对照组的83. 67%,差异有统计学意义(P 0. 05)。治疗后2组临床症状总积分明显低于治疗前,且观察组明显低于对照组,差异有统计学意义(P 0. 05)。与治疗前比较,治疗后2组CD4~+比例均明显增加,观察组CD4~+/CD8~+及IgA、IgG、IgM水平均明显升高,且明显高于对照组,差异有统计学意义(P 0. 05)。治疗后观察组气道黏性阻力(R_(20))、近咽部黏性阻力(R_(35))及呼吸道总阻抗(Zrs)明显低于治疗前,且明显低于对照组,差异有统计学意义(P 0. 05)。结论:小柴胡汤合宣肺降火汤可以明显减轻喉源性咳嗽患者临床症状,调节机体免疫功能,降低患者气道阻力,提高整体疗效,效果显著。

Observation on Therapeutic Effect of Xiaochaihu Decoction Combined with Xuanfei Jianghuo Decoction in the Treatment of Laryngeal Cough

To study the effects of Xiaochaihu Decoction and Xuanfei Jianghuo Decoction in treatment of laryngeal cough and the influence on immune function and airway resistance of patients.Methods:A total of 108 cases of patients with laryngeal cough treated in Dujiangyan People''s Hospital from November 2015 to April 2017 were selected and divided into a control group(n=49)and an observation group(n=59)according to different treatment drugs.The control group was treated with routine western medicine,and the observation group was treated with Xiaochaihu Decoction and Xuanfei Jianghuo Decoction.The 2 groups were treated for 14 days continuously.The clinical efficacy and improvement of the main clinical symptoms were compared after treatment.The ratio of T lymphocyte subsets,immunoglobulin and airway resistance in the 2 groups were compared before and after treatment.Results:The total effective rate was 99.61% in the observation group,which was significantly higher than 83.67% in the control group(P<0.05).After treatment,the total clinical symptoms score in the 2 groups were significantly lower than that before treatment and the observation group was significantly lower than the control group(P<0.01).Compared with before treatment,the ratio of CD4+ significantly increased in the 2 groups after treatment,the CD4+/CD8+ and the levels of IgA,IgG,IgM in the observation group significantly increased,and were significantly higher than those of the control group(P<0.05 or P<0.01).The R20,R35,Zrs after treatment in the observation group were significantly lower than before treatment and the control group(P<0.01).Conclusion:Xiaochaihu Decoction and Xuanfei Jianghuo Decoction can obviously reduce the clinical symptoms of patients with laryngeal cough,regulate the immune function,reduce the airway resistance and improve the overall curative efficacy and the effect is remarkable.