白竭散干预混合痔术后创面愈合的研究

目的:探讨我院制剂白竭散对混合痔术后创面愈合的促愈作用及对创面肉芽组织中EGF(表皮细胞生长因子)、VEGF(血管内皮细胞生长因子)表达的影响。方法:选取2018年10月至2018年12月安徽中医药大学第一附属医院收治的混合痔患者80例作为研究对象,按照随机数字表法分为对照组和观察组,每组40例。对照组予以常规熏洗、复方黄柏洗剂清洗换药,观察组在常规换药的基础上予以白竭散干预治疗,通过2种方法干预术后创面,观察和探讨白竭散促进混合痔术后创面愈合的临床疗效。结果:在治疗前2组EGF、VEGF表达水平和创面愈合面积差异无统计学意义(P0.05),治疗后对照组EGF、VEGF表达水平均明显高于治疗前(P 0.05);且观察组明显高于对照组(P 0.05);观察组创面愈合面积明显低于对照组(P 0.05),且愈合速度高于对照组(P 0.05)。结论:院内制剂白竭散可缩短混合痔术后创面愈合时间;在混合痔术后创面肉芽组织中EGF、VEGF表达方面有明显调节作用。

Study on the Effect of Baijie Powder on Wound Healing after Mixed Hemorrhoids Surgery

To explore the effect of Baijie Powder prepared by our hospital on the healing of wound healing after mixed hemorrhoids and the effect of EGF(epidermal growth factor)and VEGF(vascular endothelial growth factor)expression in wound granulation tissue.Methods:A total of 80 patients with mixed hemorrhoids admitted to the First Affiliated Hospital of Anhui University of Chinese Medicine from October 2018 to December 2018 were enrolled.The patients were divided into a control group and an observation group according to the random number table method,with 40 cases in each group.The control group was treated with conventional fumigation and washing with compound Huangbai lotion,and the observation group was treated with Baijie Powder on the basis of routine dressing.Two kinds of methods were used to intervene the postoperative wounds.The clinical effect of Baijie Powder on improving wound healing after mixed hemorrhoid surgery was observed and explored.Results:Before treatment,there was no significant difference in the expression of EGF,VEGF and wound healing area between the 2 groups(P>0.05).After treatment,the expression levels of EGF and VEGF in the control group were significantly higher than those before treatment(P<0.05).The observation group was significantly higher than the control group(P<0.05).The wound healing area of the observation group was significantly lower than that of the control group(P<0.05),and the healing rate was higher than that of the control group(P<0.05).Conclusion:The in-hospital preparation of Baijie Powder can shorten the healing time of wounds after mixed hemorrhoids surgery.It has a significant regulatory effect on the expression of EGF and VEGF in the granulation tissue of the wound after mixed hemorrhoids surgery.