四项生化指标在肝病诊断中的应用

目的探讨总胆汁酸(TBA)、腺苷脱氨酶(ADA)、亮氨酸氨基肽酶(LAP)、α-岩藻糖苷酶(AFU)四项指标在肝病诊断中的意义。方法采用O lympus Au640全自动生化分析仪检测91例各种肝病患者和30例健康人血清中TBA、ADA、LAP、AFU的水平,并对检测结果进行统计学分析。结果四项指标在各种肝病中均有升高,其中TBA和LAP在急性肝炎时显著升高,阳性率为90%和85%;ADA在慢性肝炎和肝硬化时升高显著,阳性率分别为80.0%和85.2%;而AFU和LAP在肝癌中显著增高,阳性率各为71.4%和92.8%。结论在急性肝炎时TBA、LAP应用价值较高;慢性肝炎时和肝硬化时,ADA应用价值较高;肝癌时,AFU、LAP应用价值较高。

Application of Four Biochemical Items in Diagnosis of Liver Disease

Objective To explore the significance of serum TBA,ADA,LAP,and AFU in diagnosis of liver diseases.Method Serum levels of TBA,ADA,LAP and AFU in 91 patients with different liver diseases and 30 healthy people were examined with Olympus Au640 auto biochemical analyzer.The results were analyzed statistically.Results Four biochemical items increased in patients with different liver diseases.The mean values of TBA and LAP in acute hepatitis patients were significantly higher than those in healthy people.The positive rates of TBA and LAP were 90% and 85%.The mean values of ADA in patients with chronic hepatitis or liver cirrhosis were significantly higher than those in healthy people.The positive rates were 80.0% and 85.2%.The mean values of AFU and LAP in liver cancer patients were significantly higher than those in healthy people.The positive rates of AFU and LAP were 71.4% and 92.8%.Conclusions TBA,LAP are valuable markers for diagnosing acute hepatitis.ADA is a valuable marker for diagnosing chronic hepatitis and liver cirrhosis.LAP and AFU are valuable markers for diagnosing liver cancer.