良性前列腺增生患者对非那雄胺治疗的依从性研究

目的:本组以应用非那雄胺治疗的门诊BPH患者为对象,研究服药依从性、停药和换药的影响因素。方法:回顾性分析门诊电子数据库资料,自2008年1月至2010年6月共入组655例初诊接受非那雄胺治疗的BPH患者,平均观察期12个月,计算依从性、停药和换药例数,采用多因素分析,分别评估其影响因素。结果:依从性良好、停药、换药比例分别为32.4%、58.0%和9.6%。年龄较大(≥60岁),非那雄胺与α受体阻滞剂联合治疗,有慢性合并症等是依从性良好的预测因子。年龄较小者易于停药和换药。非那雄胺单药治疗者易于停药。结论:年龄<60岁以及接受非那雄胺单药治疗的患者总体依从性较差,临床医生应注意提高这些人群的依从性。

Factors influencing finasteride medication compliance in outpatients with benign prostatic hyperplasia

Objective: To investigate the factors influencing the compliance,discontinuation and switching of finasteride medication in patients with benign prostatic hyperplasia(BPH).Methods: We retrospectively analyzed the electronic clinical data of 655 outpatients with BPH treated with finasteride from January 2008 to June 2010.Using the medication possession ratio(MPR),we measured their medication compliance and the rates of discontinuation and switching after an average observation of 12 months.We identified and evaluated the influencing factors by multivariate logistic regression analysis.Results: The crude rates of medication compliance,discontinuation and switching were 32.4%,58.0% and 9.6%,respectively.In those aged ≥60 years,combination therapy of finasteride with α-receptor blockers and chronic comorbidities were positively associated with good compliance,while younger age was significantly associated with drug discontinuation or switching.Finasteride monotherapy was significantly associated with discontinuation of the drug.Conclusion: Patients aged <60 years and those receiving monotherapy were less likely to be compliant with newly initiated finasteride medication,and therefore more efforts should be made to increase their medication adherence.