Prosthetic valve endocarditis secondary to Burkholderia cepacia

Prosthetic valve endocarditis is a catastrophic complication of cardiac valve replacement and is associated with high mortality rates. Endocarditis due to Burkholderia cepacia (B. Cepacia) is rare but serious, leading to valve dysfunction and heart failure. B. Cepacia is resistant to multiple antibiotics which lead to frequent treatment failures. Two cases of B. Cepacia prosthetic valve endocarditis are reviewed.