Suppression of dimethylnitrosamine metabolism and toxicity by nitrososarcosine and other nitrosamines. |
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| Authors: | M A Friedman V Sanders S Woods |
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| Affiliation: | Department of Pharmacology, Medical College of Virginia, Health Sciences Division, Virginia Commonwealth University, Richmond, Virginia 23298 USA |
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| Abstract: | Groups of rats were pretreated with nitrososarcosine (NS), diethylnitrosamine (DEN), or dibutylnitrosamine (DBN) in order to observe potential effects on dimethylnitrosamine (DMN) toxicity and metabolism. NS and DEN completely suppressed DMN-induced inhibition of liver protein synthesis while the case with DBN was not as clear. DMN metabolism was effected by suppression of DMN demethylase activity, and an inhibition of RNA, DNA, and protein methylation by [14C]DMN by each nitroso compound. |
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