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诺和龙治疗2型糖尿病60例临床疗效观察
引用本文:李素霞 张晓凡. 诺和龙治疗2型糖尿病60例临床疗效观察[J]. 中原医刊, 2006, 33(10): 10-11
作者姓名:李素霞 张晓凡
作者单位:河南科技大学第三附属医院洛阳东方医院内分泌科 洛阳471003
摘    要:目的比较诺和龙与格列吡嗪对2型糖尿病的临床疗效。方法将单纯饮食及运动治疗控制不满意的2型糖尿病患者118例,随机分为诺和龙组(60例)和格列吡嗪组(58例),疗程12周。结果诺和龙与格列吡嗪有相似的降糖效果(P<0.01),相互比较差异无统计学意义(P>0.05)。两者都能提高空腹和餐后2h血清C肽水平(P<0.05),空腹C肽水平的提高两者差异无统计学意义(P>0.05),但餐后2h C肽水平比较差异有统计学意义(P<0.05)。两者对体重指数的影响比较有临床意义(P<0.05)。两者对肝肾功能均无明显影响,诺和龙未发现明显的低血糖反应,格列吡嗪有5例出现餐前低血糖症状。结论诺和龙是一种非磺脲类的胰岛素促分泌剂,起效快,模拟生理性的胰岛素分泌,降糖效果好,对β细胞功能影响小,比格列吡嗪更完全、更方便、依从性更好。

关 键 词:糖尿病  β细胞  诺和龙  格列吡嗪
收稿时间:2006-03-10
修稿时间:2006-03-10

Repaglinide in the treatment of type 2 diabetes mellitus
LI Suxia, ZHANG Xiaofan.. Repaglinide in the treatment of type 2 diabetes mellitus[J]. Central Plains Medical Journal, 2006, 33(10): 10-11
Authors:LI Suxia   ZHANG Xiaofan.
Affiliation:Department of Endocrinology, the Third Affiliated Hospital of Itenan Science and Technology University, Luoyang 471003, Henan
Abstract:Objective To compare the clinical effect of repaglinide and glipizide in treating patients with type 2 diabetes mellitus.Methods One-hundred and eighteen cases of type 2 diabetes were randomly divided into 2 groups,treated with repaglinide(60 cases) or glipizide(58 cases)for 12 weeks.Results The lowering blood glucose effect of the two drugs was similar(P<0.01).No significant difference exited(P>(0.05)).Both drugs can increase the serum level of C-peptide in empty condition and 2h after diet(P<(0.05)).There was no significant difference about the level of C-peptide in empty(P>0.05),but it existed 2h after diet(P<0.05).The effect of the two drugs on body weight index was of significant difference((P<)(0.05)).Both drugs had no significant effect on liver and kidney.No significant hypoglycemia reaction had been induced by repaglinide,while 5 cases hypoglycemia induced by glipizide were found.Conclusion With the advantages of convenience,security,and rapid effect,repaglinide is a good blood glulose lowering drug.
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