O-methyl nakafuran-8 lactone, a new sesquiterpenoid from a hainan marine sponge Dysidea sp |
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| Authors: | Shao Z-Y Li J Sim C J Li J-Y Li Z-Y Nan F-J Guo Y-W |
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| Affiliation: | a State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, Chinab Department of Biology, Hannam University, South Korea |
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| Abstract: | A new sesquiterpenoid, O-methyl nakafuran-8 lactone (1) has been isolated from a Hainan sponge Dysidea sp. and the structure of the new compound proposed by spectral data, was confirmed by X-ray diffraction analysis. The complete 1H- and 13C-NMR assignments were made on the basis of detailed 2D NMR spectral analysis.
Compound 1 showed strong inhibitory bioactivity against PTP1B with IC50 value of 1.58 μM. |
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| Keywords: | Dysidea sp Sesquiterpenoid O-methyl nakafuran-8 lactone |
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