Relationship between plasma corticosterone and insulin levels in rats with ventromedial hypothalamic lesions |
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| Authors: | B M King C B Calvert K R Esquerré J H Kaufman L A Frohman |
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| Institution: | Department of Psychology, University of New Orleans, New Orleans, LA 70148 USA;Louisiana State University Medical Center, 1440 Canal Street, New Orleans, LA 70112 USA;Division of Endocrinology and Metabolism, University of Cincinnati College of Medicine, Cincinnati, OH 45267 USA |
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| Abstract: | The effects of ventromedial hypothalamic (VMH) lesions on plasma corticosterone, insulin, and glucose levels were studied in food-restricted and ad lib fed female rats. VMH lesions resulted in significant elevations of corticosterone and insulin levels compared to control values during the first 25 days after surgery. However, unlike insulin values which were generally greater in VMH rats fed ad lib than in food-restricted animals, plasma corticosterone levels were unaffected by level of food intake. Corticosterone and insulin levels were unrelated preoperatively and in sham-operated animals, but were positively correlated (r = .82) by Day 25 in ad lib fed VMH rats. It is concluded that the elevation in plasma glucocorticoids observed in VMH rats is a primary effect of the lesion that is independent of food intake or initial weight gain. |
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| Keywords: | Ventromedial hypothalamus Obesity Feeding behavior Glucocorticoids Insulin |
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