E-cadherin和C-erbB2在非小细胞肺癌中的表达及其临床病理意义

目的：研究非小细胞肺癌（NSCLC）中E-cadherin和C-erbB2蛋白的表达状况，分析其临床病理意义。方法：用免疫组化方法对82例非小细胞肺癌标本和20例正常肺组织进行免疫组化检测。结果：正常肺组织E-cadherin表达；4例C-erbB2＋表达，无C-erbB2过表达。NSCLC中E-cadherin表达率为（49％），低分化组NSCLCE-cadherin表达率为30％，明显低于中高分化组表达率60％（P=0．010）；中晚期（Ⅲ＋Ⅳ）NSCLC表达率为31％，明显低于早期（Ⅰ＋Ⅱ）NSCLC表达率62％（P=0．007）；淋巴结转移组NSCLC表达率为39％，低于无淋巴结转移组表达率65％（0．026），均有统计学意义。肺腺癌C-erbB2表达率为45％，高于鳞癌过表达率17％（P=0．017）；中晚期NSCLC（Ⅲ＋Ⅳ）过表达率为51％，高于早期（Ⅰ＋Ⅱ）过表达率21％（P=0．004）；淋巴转移组过表达率为41％，高于无淋巴转移组过表达率23％（P=0．028）。E-cadherin的低表达和C-erbB2过表达无相关性。结论：E-cadherin低表达和C-erbB2过表达在肺癌的发生、发展和淋巴结转移中可能扮演重要的角色，联合检测对判断NSCLC生物学行为有病理临床意义。

The Expression of E-cadherin and C-erbB2 in NSCLC and theirs Significances

Objective：To investigate the the expression of E-cadherin and C-erbB2 protein in no-small cell lung cancer （NSCLC） and analyze the relationship between their expression and pathological significance, explore the relationship between E-cadherin and C-erbB2 at protein levels. Methods ：To test the protein expression of E-cadherin and C- erbB2 in 20 normal lung tissues and 82 NSCLC tissues by immunochemistry. Results ：E-cadherin was normally expressed in all normal lung tissues ,and C-erbB2＋expression was detected in 4 case of 20 normal lung tissue but no overexpression was detected, in all NSCLC cases,the E-cadherin normal expression rate was 49% and its normal expression rate of lower differentiated group is 30% and statistically lower than that in high differentiated group（60%）; the normal expression rate of lymph transfer group was statistically lower than the group which had no lymph node transferred （P= 0. 010）;the normal expression rate （31% ）of E-cadherin in TNM Ⅲ＋Ⅳ group is significantly lower than that （62 %） in TNM Ⅰ-Ⅱ group （P=0. 003）. The overexpression rate of C-erbB2 in lung adenocarcinoma was 45.5% while overexpression rate was 19.9% in the squamous carcinoma,these differences have statistics meanings （P= 0. 039） . The overexpression rate in Lymph transfer group （43.2%） was remarkably higher than the group （18. 5% ）which has not been transferred （P=0. 033）. C erbB2 overexpression correlated with TNM staging, the overexpression of C-erbB2 in TNM Ⅲ＋Ⅳ group is significantly higher than that in TNM Ⅰ ＋ Ⅱ group （P=0. 003）. There was no relationship between E-cadherin reduced expression and C-erbb2 overexpression in NSCLC. Conclusion：E-cadherin reduced expression and C- erbB2 overexpression may play an important role in the development and lymph node metastasis of NSCLC, and the combination test of E-cadherin and cerbb2 has pathological significance for judging the biological behavior of NSCLC.