105例原发性肝癌的临床及病理特征分析

目的探讨乙型肝炎病毒（HBV）感染与原发性肝癌（PHC）之间的关系和其病理特征。方法：经病理证实的105例PHC患者，检测了解其HBV感染史和感染模式，并分析肝组织的病理学变化，以探讨乙型肝炎病毒感染与原发性肝癌（PHC）之间的关系。结果：105例PHC患者中HBV感染102例，感染率达97．1％，以HBsAg、抗-HBe和抗-HBc的阳性率最高（53．3％）。而HBsAg（＋）、HBeAg（＋）、抗-HBc阳性率次之（为23．8％），肝组织病理学特征：肝细胞癌（HCC）占94．3％（99／105），结节型、巨块型、小肝癌分别占60．9％、30．5％、和8．6％。多分布在肝右叶（占63．8％），85％合并有肝硬化。结论：HBV感染与原发性肝癌的发生关系密切，是PHC的主要病原学因素。PHC以肝细胞癌、低分化为主，主要分布在肝右叶、以结节型为主。

Analyse of Clinicals and Pathologic Features of Primary Hepatic Carcinoma: A Report of 105 Cases

Objective To investigate the relationship between infection of hepatitis B Virus(HBV) and the occurrance of primary hepatic carcinoma(PHC) and its pathologic features. Methods One hundred and five patients with PHC were diagnosed by histopathologic examination .The history of HBV infection and its infective patterns were obtained and by analysis histopathologic changes.Results The markers of HBV were positive in 102 (97.1%) out of 105 cases.The positive rate of HBsAg anti-HBe and anti-HBc was the highest among the five markers of HBV (53.3%). The positive rate of HBsAg and HBeAg and anti-HBc was 23.8%.Histopathologic features were as following:HCC accounted for 94.3%,and nodular type ,macro-type and small hepatic carcinomas accounted for 60.9% 30.5% and 8.6% respectively.The distributions PHC were mainly in right lobe of liver(63.8%).Conclusion There was a close relationship between the infection and the occurance of HBV and PHC .HBV infection is the main etiology factor for PHC.