| 异丁司特缓释胶囊随机双盲双模拟治疗支气管哮喘或喘息性支气管炎 |
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| 引用本文： | 熊盛道,刘辉国,张珍祥,徐永健.异丁司特缓释胶囊随机双盲双模拟治疗支气管哮喘或喘息性支气管炎[J].中国新药杂志,2001,10(2):113-115. |
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| 作者姓名： | 熊盛道 刘辉国 张珍祥 徐永健 |
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| 作者单位： | 同济医科大学附属同济医院呼吸内科, |
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| 摘 要： | 目的：评价异丁司特缓释胶囊治疗支气管哮喘和慢性喘息性支气管炎的疗效和安全性。方法：采用双盲双模拟随机平等对照临床试验。试验组40例，口服异丁司特缓释胶囊10mg,bid,疗程6周。对照组40例，口服曲尼司特胶囊100mg,tid，疗程6周。结果：试验组总显效率为67．5％，总有效率为90．0％。肺功能显著改善17例，中度改善11例，改善8例。治疗分数明显低于试验前（P＜0．01）。IgE值治疗后比治疗前明显降低（P＜0．01）。上述结果均与对照组相似。试验药物不良反应发生率为27．5％，且多为轻度反应，并可耐受。结论：异丁司特缓释胶囊是一种安全有效的治疗支气管哮喘和慢性喘息性支气管炎的药物。
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| 关 键 词： | 异丁司特 曲尼司特 哮喘 治疗 |
| 文章编号： | 1003-3734(2001)02-0113-03 |
A double blind,double
dummy,randomized,controlled trial of ibudilast sustained-release capsule in treatment of
asthma or chronic as thmatic bronchitis |
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| XIONG Sheng-dao,LIU Hui-guo,ZHANG Zhen-xiang,XU Yong-jian.A double blind,double
dummy,randomized,controlled trial of ibudilast sustained-release capsule in treatment of
asthma or chronic as thmatic bronchitis[J].Chinese Journal of New Drugs,2001,10(2):113-115. |
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| Authors: | XIONG Sheng-dao LIU Hui-guo ZHANG Zhen-xiang XU Yong-jian |
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| Abstract: | Objective:To evaluate the efficacy and safety of ibudila st sustained-release capsule in treatment of asthma or chronic asthmatic bronch itis.Methods:80 patients with asthma or chronic asthmatic bronchitis w ere randomly allocated to receive twice daily 10 mg ibudilast sustained-release capsule for 6 weeks or three times daily 100 mg tranilast sustained-release ca psule for 6 weeks.Results:The total significantly effective rate,total effective rate,improvement in lung function and decrease in IgE value obtained were similar in both active and control groups.Conclusion:Ibudilast su stained-release capsule is an effective agent for treatment of asthma or chroni c asthmatic bronchitis. |
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