脂肪因子研究进展

脂肪聚集可导致动脉粥样硬化、高血压、糖尿病等一系列肥胖相关性疾病。近年来的研究发现,脂肪组织是一个代谢活跃的内分泌器官,可分泌多种脂肪因子,其中一部分为传统意义上的激素,如瘦素、脂联素、抵抗素、内脂素等;另一些与炎症及免疫相关的细胞因子相同,如肿瘤坏死因子-α、白细胞介素-6等。脂肪组织通过脂肪因子与许多器官、组织,如心血管、肝脏、肌肉、胰腺等进行对话,从而广泛地影响和调节机体的能量代谢及各种功能。本文将脂肪因子的作用及近年来的研究进展综述如下。

Adipocytokines:Factors with Various Suggested Functions

Fat accumulation has been shown to play important roles in the development of obesity-related disorders such as atherosclerosis,diabetes mellitus and hypertension.Recent studies have shown that fat tissue is not a simple energy storage organ,but exerts important endocrine functions.These are achieved predominantly through release of adipocytokines,which include several novel molecules released by adipocytes like leptin,resistin,adiponectin or visfatin,as well as some more classical cytokines released possib...