肺癌组织中结核菌L型的检出与意义

目的 探讨结核菌Ｌ型与肺癌的可能关系。方法应用改良抗酸染色法及免疫酶染色法，对９６例经纤维支气管镜活检标本及２０例手术切除肺标本进行结核菌及其Ｌ型检测，结果：９３例肺癌组织抗酸染色及免疫酶染色阳性率分别为３８．７１％和５１．６１％，均高于非肺癌非肺结核（对照）组（Ｐ〈０．０１和Ｐ〈０．０５），抗酸染色所检出的结核菌除１例为典型杆菌外，其余都为Ｌ型，免疫酶染色阳性中，有２９．７１％阳性颗粒见于癌细胞

Isolation of acid-fast bacillus L-forms from carcinoma of Lung

Objective:To study the possible relationship between acid fast bacillus L forms and lung carcinoma.Methods:Intensified Kinyoun's acid fast staining and immunoenzyme staining were used for examining in 96 specimens obtained from fibroptic bronchoscopic biopsy and 20 specimens obtained from pulmonectomy.Results:In 93 specimens showed to have lung cancer positive rates of acid fast staining and immunoenzyme staining were 38.71% and 51.61%,respectively,their positive rates were much higher than that in nontuberculosis and noncancer specimens( P <0.01 and P <0.05).The acid fast organisms found were all in L forms except one in bacillus forms.Immunoenzyme staining positive were found intracellular in 29.17% and intranuclei in 6.25% of the cancer patients.Conclusions:The DNA of the wall defective mycobacterial L forms may integrate into host DNA and lead to carcinoma formation,the mechanism may be similar to the carcinogenesis of virus.