| 调节博来霉素生物合成基因的研究进展 |
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| 引用本文： | 陈建国,何琪杨. 调节博来霉素生物合成基因的研究进展[J]. 国外医药(抗生素分册), 2010, 31(5): 197-201 |
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| 作者姓名： | 陈建国 何琪杨 |
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| 作者单位： | 中国医学科学院北京协和医学院医药生物技术研究所,北京,100050 |
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| 摘 要： | 博来霉素为氨基糖肽类抗肿瘤抗生素，具有良好的抗肿瘤活性。本文介绍了博来霉素生物合成基因的研究进展，包括博来霉素生物合成基因各基因的结构和功能、BlmIX／BlmⅧ／BlmⅦ组成的杂合系统和磷酸泛酰巯基乙胺基转移酶对杂合系统中的载体蛋白的翻译后修饰作用。
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| 关 键 词： | 博来霉素 生物合成基因 杂合系统 磷酸泛酰巯基乙胺基转移酶 |
Progress on the Regulation of the Biosynthetic Genes of Bleomycin |
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| Chen Jian-guo,He Qi-yan. Progress on the Regulation of the Biosynthetic Genes of Bleomycin[J]. world notes on antibiotics, 2010, 31(5): 197-201 |
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| Authors: | Chen Jian-guo He Qi-yan |
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| Affiliation: | Chen Jian-guo, He Qi-yan (Institute of Medicinal Biotechnology, Peking Union Medical College ＆Chinese Academy of Medical Sciences, Beijing 100050) |
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| Abstract: | The antitumor drug bleomycin belongs to aminoglycopeptide antibiotics which shows high antitumor activity. Research progress on the biosynthetic genes of the bleomycin was summarized in this paper, including the structures and functions of the biosynthetic genes, a natural hybrid system constituted by BImIX/BlmⅧ BImⅦ,as well as the post-translational modification of the hybrid system by the Svp PPTase with broad carrier Protein specificity. |
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| Keywords: | bleomycin biosynthetic gene hybrid system PPTase |
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