| 阿苯达唑微球肝动脉灌注对大鼠肝泡状棘球蚴病的治疗作用 |
| |
| 引用本文： | 樊玉祥,任伟新,迪力木拉提·巴吾冬,顾俊鹏,许晓东,张海潇,纪卫政,姜涛,温浩.阿苯达唑微球肝动脉灌注对大鼠肝泡状棘球蚴病的治疗作用[J].中国寄生虫学与寄生虫病杂志,2011(6). |
| |
| 作者姓名： | 樊玉祥 任伟新 迪力木拉提·巴吾冬 顾俊鹏 许晓东 张海潇 纪卫政 姜涛 温浩 |
| |
| 作者单位： | 新疆医科大学第一附属医院介入放射科;新疆医科大学第一附属医院新疆包虫病临床研究所; |
| |
| 摘 要： | 目的观察阿苯达唑-PEG6000固体分散体壳聚糖微球经肝动脉灌注治疗大鼠肝泡状棘球蚴病的效果。方法将肝泡状棘球蚴病模型大鼠30只,随机均分为3组,即生理盐水对照组(A)、空白微球组(B)和阿苯达唑微球组(C),A、B和C组分别经肝动脉灌注0.3 ml生理盐水、空白微球2.7 mg/kg(溶于0.3 ml生理盐水)、阿苯达唑-PEG6000固体分散体壳聚糖微球2.7 mg/kg(溶于0.3 ml生理盐水)。于灌注后第1、3、7、14和42天采集大鼠外周静脉血,检测白细胞(WBC)、门冬氨酸氨基转移酶(AST)和丙氨酸氨基转移酶(ALT)的值。第42天处死全部大鼠,取肝泡状棘球蚴组织,观察各组病理变化。结果各组大鼠白细胞第1天出现暂时性升高A组(86.11±19.14)×109/L、B组(117.11±21.76)×109/L和C组(118.11±24.52)×109/L],第7天恢复正常A组(7.85±6.57)×109/L、B组(11.73±4.85)×109/L和C组(8.49±1.36)×109/L]。B、C组在第3天AST、ALT达到最高值B组AST(193.15±21.57)U/L、ALT(78...
|
| 关 键 词： | 阿苯达唑 壳聚糖微球 肝泡状棘球蚴病 灌注 |
Therapeutic Effect of Hepatic Artery Infusion with Albendazole Microspheres on Hepatic Alveolar Echinococcosis in Rats |
| |
| Institution: | FAN Yu-xiang1,REN Wei-xin1,BAWUDUN·Dilmurat1,GU Jun-peng1,XU Xiao-dong1,ZHANG Hai-xiao1,JI Wei-zheng2,JIANG Tao2,WEN Hao2 (1 Department of Interventional Radiology,The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China,2 Clinical Institute of Hydatid Disease,China) |
| |
| Abstract: | Objective To observe therapeutic effect of hepatic artery infusion of albendazole solid dispersion-chitosan microspheres on hepatic alveolar echinococcosis(HAE) in rats.Methods After the establishment of hepatic alveolar echinococcosis model,30 rats were randomly divided into control group(A),blank microspheres group(B),and albendazole microspheres group(C) with 10 rats in each group.0.3 ml normal saline,2.7 mg/kg blank microspheres and 2.7 mg/kg albendazole solid dispersion-chitosan microspheres with 0.3 m... |
| |
| Keywords: | Albendazole Chitosan microsphere Hepatic alveolar echinococcosis Infusion |
| 本文献已被 CNKI 等数据库收录！ |
|
