麻痹性痴呆临床特征分析

目的 分析麻痹性痴呆（GPI）的临床及影像特征有助于临床医生熟悉神经梅毒。方法 回顾性分析经临床及实验室确诊的1例麻痹性痴呆患者的有关临床资料。结果 麻痹性痴呆早期以认知及精神症状为主要表现,影像上主要为脑萎缩,血及脑脊液TRUST和TPPA阳性,脑脊液常规检查示WBC20×10^6/L,蛋白1.0g/L。经大剂量青霉素治疗2个月后患者症状渐渐消失。结论 本例患者诊治经过提示对痴呆综合征患者进行梅毒检查的必要性。对早期神经梅毒,大剂量青霉素治疗能取得显著疗效。

Analyse on the clinical and image features of general paresis of the insane

Objective To analyse the clinical and image features of general paresis of the insane(GPI)in order to improve the knowledge of the clincians about neurosyphilis.Methods The clinical、laboratory data and cranial MRI of the definite one case GPI was analysed by a retrospective method.Results The early chief manifestitions of GPI were cognitive and psychiatric symptoms,whose magnetic resonance image(MRI)showed cerebral atrophy.The detest results of TRUST and TPPA were positive including serum and cerebrospinal fluid in the case.Cerebrospinal fluid analysis showed:WBC 20×106/L,and protein 1.0 g/L.His neuropsychiatric sysmptoms recovered gradually after 2 months penicillin treatment.Conclusion It's necessary to investigate the possibility of neurosyphillis in subjects with dementia syndrome.With a large dose and sufficient courses of penicillin treatment GPI might hope fully get predominant effects if it were diagnosed earlier.