乳腺浸润性导管癌免疫表型分化规律及临床意义

目的:探讨乳腺癌免疫表型分化规律及临床意义。方法:采用免疫组化SP法检测CK5、CK8及P63在136例乳腺浸润性导管癌中的表达,分析乳腺癌免疫表型分化规律及其与临床病理特征的关系。结果:CK5在乳腺浸润性导管癌中表达较弱,CK8在乳腺浸润性导管癌表达较强;109例(80.15%)乳腺浸润性导管癌呈现CK5-/CK8+腺腔表型,9例(6.62%)呈现CK5+/CK8-干细胞表型,15例(11.03%)呈现CK5+/CK8+混合表型,3例(2.21%)呈现CK5-/CK8-表型,且这种表达与患者的年龄、肿瘤分化程度、淋巴结转移以及临床分期相关;P63在乳腺浸润性导管癌中有11例(8.81%)呈现少量的肿瘤细胞阳性,并且主要表达于低分化的乳腺癌中。结论:CK5+/CK8+、CK5+/CK8-或P63+表型乳腺癌恶性程度高、预后差,免疫表型可作为评价预后的生物学指标。

Clinical significance and rule of phenotypic differentiation in invasive ductal carcino-ma

Objective:To explore the clinical significance and rule of phenotypic differentiation in invasive ductal carcinoma.Methods:The expression levels of CK5,CK8 and P63 in 136 case with invasive ductal carcinoma were detected by immunohistochemical staining,the relationship between phenotypic differentiation and clinical-pathological characteristics was analysed.Results:The expression of CK5 was low in invasive ductal carcinoma,while the expression of CK8 was high.109 cases (80.15%) showed CK5-/CK8+ phenotype,9 cases (6.62%) showed CK5+/CK8-phenotype,15 cases (11.03%) showed CK5+/CK8+ phenotype and 3 cases (2.21%) showed CK5-/CK8-phenotype,which was related to patients' age,tumor differentiation level,lymph node metastasis and clinical staging.The expression of P63 in invasive ductal carcinoma was low,11 cases (8.81%) showed rare neoplastic cells positive.Conclusion:CK5+/CK8+,CK5+/CK8-or P63+ phenotypes breast cancer is high malignant,bad prognosis,and the phenotype might be a novel molecular marker to predicate the progression of invasive ductal carcinoma.