Cytotoxic triterpenes fromCrataegus pinnatifida |
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Authors: | Byung Sun Min Young Ho Kim Sang Myung Lee Hyun Ju Jung Jun Sung Lee Min Kyun Na Chong Ock Lee Jong Pill Lee KiHwan Bae |
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Institution: | College of Pharmacy, Chungnam National University, Taejon, Korea. |
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Abstract: | Bioassay-guided fractionation of Crataegus pinnatifida (Rosaceae) gave two cytotoxic ursane-type triterpenes which were identified as uvaol (1) and ursolic acid (2) by physicochemical and spectroscopic methods. 3-Oxo-ursolic acid (3) was synthesized from ursolic acid (2) by Jones method. The cytotoxic activities of these compounds were tested against murine L1210 and human cancer cell lines (A549, SK-OV-3, SK-MEL-2, XF498, and HCT15) in vitro. Compounds 1 and 2 showed moderate cytotoxicities against L1210, whereas they showed weak activities against human cancer cell lines. However, compound 3 exhibited potent cytotoxic activities both in murine and in human cancer cell lines. |
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Keywords: | Crataegus pinnatifida Rosaceae Uvaol Ursolic acid 3-Oxo-ursolic acid Cytotoxicity |
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