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| nm23、p53基因突变与膀胱癌生物学特性的关系 | |
| 引用本文： | 徐忠华,李甦,郭晨红,赵春华,郑宝钟,田军,刘照军,玄绪军,周尊林,崔先泉.nm23、p53基因突变与膀胱癌生物学特性的关系[J].山东大学学报(医学版),2000,38(1):17-19. |
| 作者姓名： | 徐忠华 李甦 郭晨红 赵春华 郑宝钟 田军 刘照军 玄绪军 周尊林 崔先泉 |
| 作者单位： | 1. 山东医科大学,附属医院泌尿外科 2. 山东医科大学,遗传学教研室 3. 山东医科大学,生物化学教研室 |
| 摘 要： | 检测膀胱癌组织中nm23和p53基因外显子突变情况，寻找有助于准确预测局部肿瘤进展、分型、预后情况的临床参照指标。 方法应用PCR－SSCP检测28例膀胱癌术后存档蜡块组织中nm23及p53基因外显子突变情况，并与膀胱癌的病理及临床指标进行相关性研究。结果nm23及p53基因突变率分别为14.3％及17.99％。nm23及p53基因突变均发生在低分化组及有淋巴结转移病例。nm23和／或p53基因突变与UICC临床分期和淋巴结转移均呈正相关(P |
| 关 键 词： | 基因，nm23 基因，p53 膀胱肿瘤 |
| 文章编号： | 1000-0496(2000)01-0017-03 |
| 修稿时间： | 1999-11-11 |
MUTATION AND SIGNIFICANCE OF TUMOR METASTASIS SUPPRESSOR GENE nm23 AND SUPPRESSOR GENE p53 IN BLADDER CANCER |
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| XU Zhong-hua ,LI Su ,GUO Chen-hong.MUTATION AND SIGNIFICANCE OF TUMOR METASTASIS SUPPRESSOR GENE nm23 AND SUPPRESSOR GENE p53 IN BLADDER CANCER[J].Journal of Shandong University:Health Sciences,2000,38(1):17-19. | |
| Authors: | XU Zhong-hua LI Su GUO Chen-hong |
| Institution: | XU Zhong-hua ,LI Su ,GUO Chen-hong ;(Dept. of Urology , the Affiliated Hospital of Shandong Medical University) |
| Abstract: | Objective: Our study aimed to investigate whether nm23 and p53 gene mutation in the primary bladder tumor correlated with tumor grade stage recurrence metastasis and patient survival time. Methods:PCR SSCP is used to test the exon mutation in nm23 and p53 of the samples. 28 cases paraffin embeded samples were admitted. Results: The gene mutation rate of nm23 and p53 were 14.3% and 17.9%. All mutations happened in the low grade tumor and lymph node metastasis. In this study, nm23 and p53 gene mutation was correlated with histological grade and clinical stage and closely correlated with lymph node metastasis. Conclusion: We found that nm23 and p53 play an important role in the development and progression of bladder cancer. nm23 and p53 appear to be associated with the proliferation and progression of bladder cancer. Both of them can be used as prognostic factors in bladder cancer. |
| Keywords: | Genes nm23 Genes p53 Bladder neoplasms |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |