| 重组人白介素-11治疗复发重症特发性血小板减少性紫癜的临床观察 |
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| 引用本文： | 贺艳娟,李晓林,祝焱,赵谢兰,舒毅刚.重组人白介素-11治疗复发重症特发性血小板减少性紫癜的临床观察[J].中国现代医学杂志,2008,18(21):3187-3189. |
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| 作者姓名： | 贺艳娟 李晓林 祝焱 赵谢兰 舒毅刚 |
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| 作者单位： | 中南大学湘雅医院血液科,湖南,长沙,410008 |
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| 摘 要： | 目的 观察重组人白介素-11对复发的重症特发性血小板减少性紫癜(ITP)疗效.方法 17例18人次复发的重症特发性血小板减少性紫癜患者在使用原剂量肾上腺皮质激素基础上,用重组人白介素-111.5mg/d皮下注射,疗程5～10d.并分别于治疗前、治疗后第3天、第5天、第7天、第10天复查外周血血小板.结果 14例患者血小板计数在5～10 d上升至正常,2例次明显上升但低于正常,2例略有提高.结论 重组人白介素-11可以有效促进ITP患者外周血血小板计数的恢复,快速控制ITP患者的出血症状.
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| 关 键 词： | 重组人白介素-11 血小板减少性紫癜 肾上腺皮质激素 |
Clinical study of recombinant human interleukin-11 on refractory idiopathic thrombocytopenic purpura with severe symptom |
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| HE Yan-juan
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LI Xiao-lin
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ZHU Yan
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ZHAO Xie-lan
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SHU Yi-gang.Clinical study of recombinant human interleukin-11 on refractory idiopathic thrombocytopenic purpura with severe symptom[J].China Journal of Modern Medicine,2008,18(21):3187-3189. |
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| Authors: | HE Yan-juan LI Xiao-lin ZHU Yan ZHAO Xie-lan SHU Yi-gang |
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| Institution: | HE Yan-juan,LI Xiao-lin,ZHU Yan,ZHAO Xie-lan,SHU Yi-gang(Department of Hematology,Xiangya Hospital,Central South University,Changsha,Hunan 410008,P.R.China) |
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| Abstract: | Objective To explore the clinical efficacy of recombinant human interleukin-11 on recurrence idiopathic thrombocytopenic purpura with severe symptom.Method18 times of 17 patients were treated with 1.5 mg/ d of recombinant human interleukin-11 by subcutaneous injection five to ten days, meanwhile, the previous dose of adrenocortical hormones were taken.Result The platelet count of 14/18 patients rose to normal and bleeding symptom were controlled, 2/18 patients platelet count had obviously improved, 2/18 pat... |
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| Keywords: | recombinant human interleukin-11 idiopathic thrombocytopenic purpura adrenocortical hormones |
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