Differential effects of CD4+ and CD8+ cells in acute, systemic murine candidosis. |
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| Authors: | L A Coker C M Mercadal B T Rouse R N Moore |
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| Affiliation: | Department of Microbiology, College of Liberal Arts, University of Tennessee, Knoxville 37996-0845. |
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| Abstract: | Monoclonal antibody (mAb) depletion was used to assess contributions of CD4+ and CD8+ cells in resistance to systemic murine Candida albicans infection. Depletion of CD8+ cells did not influence either survival or mean survival time (MST); however, depletion of CD4+ cells significantly enhanced both survival and MST. Combined depletion of both CD4+ and CD8+ cells significantly lengthened the MST but did not enhance survival. A protective influence of CD8+ cells could be deduced but, to be manifested, required depletion of an overshadowing immunopathologic CD4+ response. |
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