Inflammatory cell adhesion and surface defects on heparin-surface-modified poly(methyl methacrylate) intraocular lenses in diabetic patients

PURPOSE: To evaluate the incidence of surface scratches on heparin-surface-modified (HSM) poly(methyl methacrylate) (PMMA) intraocular lenses (IOLs) and the possible influence of these alterations on the biocompatibility of HSM PMMA. SETTING: University Eye Clinic of Trieste, Trieste, Italy. METHODS: Twenty-six diabetic patients had phacoemulsification and implantation of an HSM PMMA IOL (809C, Pharmacia & Upjohn). Patients with proliferative diabetic retinopathy or iridopathy were excluded from the study. On postoperative days 7, 30, 90, and 180, specular microscopy was performed to study and photograph the anterior IOL surface. The presence of scratches on the anterior IOL surface was assessed and the inflammatory cell reaction noted and graded using a semiquantitative scale. Finally, the location of the inflammatory cells in relation to the surface scratches was established. RESULTS: Scratches and other surface defects were found in 88.4% of cases. All patients had small cells on the IOL surface 7 days after surgery. At 30 days, small cells were observed in 88.4% of cases. The inflammatory cells were mainly located inside the scratches rather than throughout the IOL surface. CONCLUSIONS: This in vivo cytology study provides further evidence of the effectiveness of heparin surface modification in improving the biocompatibility of PMMA. In diabetic patients, inflammatory cells adhered to the exposed PMMA surface more than to the HSM surface, suggesting that the use of HSM PMMA in patients with conditions predisposing them to increased postoperative blood-aqueous barrier breakdown is beneficial.