血浆和脑脊液中白介素-6水平变化在新生儿颅内出血的意义

目的研究新生儿颅内出血中血浆和脑脊液白介素-6(IL-6)的水平变化与临床意义。方法采用ELISA法测定了新生儿血浆、脑脊液IL-6的含量(新生儿颅内出血22例为实验组,无窒息史、严重感染及神经系统疾病的入院新生儿13例为对照组)。结果实验组血浆、脑脊液中IL-6含量均显著高于对照组(P<0.01,P<0.001),以脑脊液升高更为显著;大出血组其IL-6含量较小出血组均显著升高(P值均为P<0.05);颅高压组其IL-6含量较正常颅压组均显著升高(P<0.05,P<0.01),以脑脊液升高明显。结论新生儿颅内出血患儿血浆和脑脊液中IL-6水平变化与脑损伤严重程度有关,是病情监测和判断预后的指标之一。

Clinical Effect of IL-6 in Plasma and CSF of Intracranial Hemorrhage of the Newborn

Objective To evaluate the change of interleukin-6(IL-6)in plasma and cerebrospinal fluid(CSF)of intracranial hemorrhage of the newborn.Methods The level of IL-6 in plasma and CSF were measured in 22 cases of intracranial hemorrhage of the newborn and 13 cases of normal group by enzyme-linked immunosorbent assay.Results The level of IL-6 in plasma and CSF in the experiment group were obviously higher than the contrast group (P<0.01,P<0.001),especially in CSF.IL-6 in plasma and CSF in the massive hemorrhage group distiactly higher than the small quantity of hemorrhage group(all P<0.05).IL-6 in plasma and CSF in cranial high pressure group were higher than the group of normal cranial pressure(P<0.05,P<0.01),especially in CSF.Conclusion The change of IL-6 level in plasma and CSF in intracranial hemorrhage of the newborn is related to the severity of brain damage.It is the one of criterion in supervising the state of an illness and estimating prognosis.