| PATHOLOGICAL STUDIES ON THE ANTI－INVASIVE CHARACTER BY RECOMBINANT HUMAN INTERLEUKIN－6 GENE－TRANSFECTED MOUSE LEUKEMIA CELLS |
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| 引用本文： | 葛林阜,曹雪涛,马大烈,李劲松,张福州,于益芝,叶天星. PATHOLOGICAL STUDIES ON THE ANTI－INVASIVE CHARACTER BY RECOMBINANT HUMAN INTERLEUKIN－6 GENE－TRANSFECTED MOUSE LEUKEMIA CELLS[J]. 中国癌症研究, 1996, 8(4): 249-252. DOI: 10.1007/BF02954741 |
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| 作者姓名： | 葛林阜 曹雪涛 马大烈 李劲松 张福州 于益芝 叶天星 |
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| 作者单位： | Ge Linfu ;Cao Xuetao; Ma Dalie;Li Jinsong;Zhang Fuzhou ;Yu Yizhi;Ye Tianxing(General Hospital of Jinan Command PLA，Jinan，250031) (Second Military Medical University，Shanghai，200433) |
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| 摘 要： | ＰＡＴＨＯＬＯＧＩＣＡＬＳＴＵＤＩＥＳＯＮＴＨＥＡＮＴＩ－ＩＮＶＡＳＩＶＥＣＨＡＲＡＣＴＥＲＢＹＲＥＣＯＭＢＩＮＡＮＴＨＵＭＡＮＩＮＴＥＲＬＥＵＫＩＮ－６ＧＥＮＥ－ＴＲＡＮＳＦＥＣＴＥＤＭＯＵＳＥＬＥＵＫＥＭＩＡＣＥＬＬＳＧｅＬｉｎｆｕ葛林阜，Ｃａｏ...
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Pathological studies on the anti-invasive character by recombinant human interleukin-6 gene-transfected mouse leukemia cells |
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| Linfu Ge,Xuetao Cao,Dalie Ma,Jinsong Li,Fuzhou Zhang,Yizhi Yu,Tianxing Ye. Pathological studies on the anti-invasive character by recombinant human interleukin-6 gene-transfected mouse leukemia cells[J]. Chinese Journal of Cancer Research, 1996, 8(4): 249-252. DOI: 10.1007/BF02954741 |
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| Authors: | Linfu Ge Xuetao Cao Dalie Ma Jinsong Li Fuzhou Zhang Yizhi Yu Tianxing Ye |
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| Affiliation: | 1. General Hospital of Jinan Command, PLA, 250031, Jinan
2. Second Military Medical University, 200433, Shanghai
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| Abstract: | Mouse FBL-3 erythroleukemia cells were transfected with recombinant human interleukin-6 (rhIL-6) gene and a clone secreting IL-6 was selected (i.e., FBL-3-IL-6 ). The cell clone secreting IL-6 was inoculated into C57BL/6 mouse. The growth of tumors was observed and histologic analyses of the tumors in situ, liver, spleen and bone marrow were performed after inoculation. The mice inoculated with wild-type FBL-3 erythroleukemia cells were used as the control. The results showed that the later the tumor occurrence, the slower the tumor development,the lower the pathological changes degree and the longer the survival time in experimental group compared to that of the control. The results demonstrated that the inoculation of the FBL-3 cell clone secreting IL-6 can inhibit the invasion of leukemia cells, suggesting that the FBL-3-IL-6 cells can he used as a vaccine to treat leukemia. |
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| Keywords: | Leukemia Experimental interleujin-6 gene transfer Invasion of leukemia cells |
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