| 应用MRI和电镜观察pSVPoMact微基因修饰雪氏细胞移植对损伤脊髓的修复作用 |
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| 引用本文： | 陈礼刚,高立达,曾凡俊,顾明,李讯,黄茂清,毛伯镛.应用MRI和电镜观察pSVPoMact微基因修饰雪氏细胞移植对损伤脊髓的修复作用[J].中国组织工程研究与临床康复,2001,5(8):156-157. |
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| 作者姓名： | 陈礼刚 高立达 曾凡俊 顾明 李讯 黄茂清 毛伯镛 |
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| 作者单位： | CHEN Li－gang（.General Hospital of Chengdu Command, Chengdu 610083,China）
高立达（1st Affiliated Hospital of West
China University of Medical Science）
ZENG Fan－jun（General Hospital of Chengdu Command, Chengdu 610083,China）
GU Ming（General Hospital of Chengdu Command, Chengdu 610083,China）
LI Xun（General Hospital of Chengdu Command, Chengdu 610083,China）
HUANG Mao－qing（General Hospital of Chengdu Command, Chengdu 610083,China）
MAO Bo－yong（1st Affiliated Hospital of West China University of Medical Science） |
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| 摘 要： |
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| 修稿时间： | 2000年12月21 |
MRI and EM Observation of
Repair Effect of Implantation of Microgene pSVPoMcat Modified SC on Injured Spinal Cord |
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| Abstract: | Objective To approach the effect of microgene pSVPoMcat modified Schwann cell (SC) on the regeneration and repair of injured spinal cord.Method Spinal cord hemi－ transection models were made with the cutting method in healthy SD rats. Microgene pSVPoMcat modified SC(group A),highly purified SC(group B),and glutin sponge (control group C)were randomly implanted into the cut. After 3 month living ,the host rats were scanned by MRI, and observed under EM. Result Spinal signals at the injury region nearly recovered to normal in group A.No recovery was found in group B.Malacosis was found in group C.TEM findings: regeneration of large number of myelinated and nonmyelinated axons and SC proliferation in group A, myelinated axon regeneration and SC necrosis in group B, non myelinated and nonmyelinated axon in group C.Conclusion Implantation of microgene pSVPoMcat modified SC could promote the repair of injured spinal cord. |
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