HLA antigens in Behçet's disease with refractory ocular attacks |
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| Authors: | K Matsuki T Juji K Tokunaga M Mochizuki K Hayashi Y Fujino J Numaga H Yamashita |
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| Institution: | Blood Transfusion Service, Tokyo University Hospital, Tokyo, Japan;Department of Anthropology, Faculty of Science, Tokyo University, Tokyo, Japan;Department of Ophthalmology, School of Medicine, Tokyo University, Tokyo, Japan |
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| Abstract: | HLA class I, II, and III antigens were studied in Japanese patients with Beh?et's disease with refractory ocular attacks. In addition to the increased frequency of B51, DQw3, especially TA10-negative DQw3, was increased and DQw1 was decreased significantly in this subgroup of Beh?et's disease. As for complement markers, C4A Q0 was increased. A rare variant of BF S07 was first observed in Japanese. Although the mechanism for the DQw3 association is obscure, a possible hypothesis is that an immune-response or immune-suppression gene linked to the DQ antigens modulates the disease severity and the efficacy of treatments. |
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