| CALPAIN-10基因与糖尿病相关性研究进展 |
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| 引用本文： | 李琳琳,张月明. CALPAIN-10基因与糖尿病相关性研究进展[J]. 中国药理学通报, 2003, 19(6): 618-621 |
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| 作者姓名： | 李琳琳 张月明 |
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| 作者单位： | 新疆医科大学药学院药理学教研室,乌鲁木齐,830054 |
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| 基金项目： | 国家自然科学基金,No 30160091 |
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| 摘 要： | CALPAIN-10(CAPN-10)是一个Ca~(2+)依赖性的半胱氨酸蛋白酶的家族,其基因编码672个氨基酸,有15个外显子,其全长为31 kb。最新研究发现,CAPN10的3种多态性及变异同时存在,可使糖尿病的危险性增加3倍,近年来世界各国学者在不同种群中就CAPN-10与Ⅱ型糖尿病的关系进行着研究,发现两者的关系有正相关也有负相关,且存在着种族差异性。
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| 关 键 词： | CALPAIN-10 基因多态性 Ⅱ型糖尿病 |
| 文章编号： | 1001-1978(2003)06-0618-04 |
| 修稿时间： | 2002-09-18 |
Research advances in the impact of calpain-10 gene on type 2 diabetes |
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| LI Lin-Lin,ZHANG Yue-Ming. Research advances in the impact of calpain-10 gene on type 2 diabetes[J]. Chinese Pharmacological Bulletin, 2003, 19(6): 618-621 |
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| Authors: | LI Lin-Lin ZHANG Yue-Ming |
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| Abstract: | The CAPN10 gene, which encodes calpain-10 ( CAPN10 ), a nonlysosomal cysteine protease expressed in many tissues, including skeletal muscle, liver, and pancreas, was positionally cloned within the NIDDM1 region. This putative diabetes susceptibility gene encodes a 672 amino-acid protein. Horikawa et al, determined that the CAPN10 gene consists of 15 exons and spans 31 kb. Recently, researchers in many countries have examined the impact of CAPN-10 gene on T2DM. The three SNPs existence simultaneously can increase threefold risk of T2DM. The correlation between them with racial diversity is also reviewed. |
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| Keywords: | CAPN-10 SNPs T2DM |
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