皖贝止咳胶囊的祛痰、镇咳药效学研究

目的：研究皖贝止咳胶囊在镇咳祛痰方面的药效。方法：镇咳实验采用小鼠氨水引咳和电刺激猫喉上神经引咳；祛痰实验采用小鼠酚红法和大鼠毛细血管法。结果：皖贝止咳胶囊的不同剂量对氨水引发的小鼠咳嗽反应有明显的止咳作用；对电刺激猫喉上神经产生的咳嗽反应，有明显的镇咳作用；采用酚红法和大鼠毛细血管法，检测到皖贝止咳胶囊对大、小鼠有显著的排痰作用。经统计学处理，与模型对照组有显著性差异，P〈0．05或P〈0．01。结论：皖贝止咳胶囊具有较强的镇咳和祛痰功效，其药效优于阳性对照药必嗽平，值得临床推广应用。

Pharmacodynamical Research on Expectorant & Antitussive Effects of Wanbei Capsule

Objective： To study pharmacodynamics of the expectorant and antitussive effects of Wanbei Anti-cough Capsule. Methods： Amm- omia and electronic stimuli acted respectively in mice and at cats＇ superior laryngeal nerve to induce cough. Phenolsulfonphthalein Test in mice and capillary method in rats were used in expectorant test. Results：Various doses of Wanbei Capsule had obvious antitussive effects in rats and cats. In expectorant test, Wanbei Capsule made fascinating expectorant effects in rats and mice with a significant difference with that of the model control groups （ P 〈 0.05 or P 〈 0.01 ）. Conclusions： Showing a relatively strong expectorant and antitussive effect, Wanbei Anti-cough Capsule had better curative effect than the positive control medicine-bromhexine hydrochloride and is advisory for application.