Ca2+ signaling by T-type Ca2+ channels in neurons |
| |
Authors: | Lucius Cueni Marco Canepari John P Adelman Anita Lüthi |
| |
Institution: | (1) Division of Pharmacology and Neurobiology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland;(2) Vollum Institute, OHSU, Portland, OR 97239, USA;(3) Department of Cell Biology and Morphology, Faculty of Biology and Medicine, University of Lausanne, Rue du Bugnon 9, CH-1005 Lausanne, Switzerland |
| |
Abstract: | Among the major families of voltage-gated Ca2+ channels, the low-voltage-activated channels formed by the Cav3 subunits, referred to as T-type Ca2+ channels, have recently gained increased interest in terms of the intracellular Ca2+ signals generated upon their activation. Here, we provide an overview of recent reports documenting that T-type Ca2+ channels act as an important Ca2+ source in a wide range of neuronal cell types. The work is focused on T-type Ca2+ channels in neurons, but refers to non-neuronal cells in cases where exemplary functions for Ca2+ entering through T-type Ca2+ channels have been described. Notably, Ca2+ influx through T-type Ca2+ channels is the predominant Ca2+ source in several neuronal cell types and carries out specific signaling roles. We also emphasize that Ca2+ signaling through T-type Ca2+ channels occurs often in select subcellular compartments, is mediated through strategically co-localized targets, and is
exploited for unique physiological functions.
Lucius Cueni and Marco Canepari contributed equally to this review. |
| |
Keywords: | Cav3 channel Low-threshold burst Oscillation Thalamus SK channel SERCA |
本文献已被 PubMed SpringerLink 等数据库收录! |
|