Effect of uridine of presynaptic NMDA and kainate receptor of rat brain cortex |
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| Authors: | L. N. Petrova A. V. Gabrelian |
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| Affiliation: | (1) Laboratory of Neurochemistry of Physiologically Active Substances, Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russia |
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| Abstract: | It was demonstrated that uridine affects presynaptic NMDA and kainite receptors of rat brain cortex. Uridine considerably inhibited 45Ca2+ uptake into synaptoneurosomes (IC50=7.1×10−12 M) under conditions NMDA stimulation and increased it under conditions AMPA stimulation (157.8%). __________ Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 145, No. 3, pp. 288–290, March, 2008 |
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| Keywords: | uridine presynaptic NMDA and kainite receptors synaptosomes 45Ca2+ uptake |
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