解毒活血法对急性冠脉综合征患者PCI术后CD40L及IL-8表达的影响

目的：观察解毒活血中药对急性冠脉综合征（ACS）患者经皮冠状动脉介入（PCI）术后CD40L及白细胞介素（IL）-8表达的影响。方法：PCI术后的50例ACS患者被随机分为常规治疗组（25例,予常规西药治疗）,中药治疗组（25例,在常规西药治疗基础上加用活血解毒中药治疗）,检测治疗前后血清中CD40L及IL-8的表达水平。结果：治疗后,与常规治疗组比较,中药治疗组CD40L（1.60±0.62）ng/ml比（1.35±0.49）ng/ml]及IL-8（6.03±0.69）ng/ml比（5.33±0.62）ng/ml]表达水平均显著降低（P均〈0.05）;中药治疗组临床疗效优于常规治疗组（总有效率：92%比72%,P〈0.05）。结论：解毒活血中药能明显降低急性冠脉综合征患者PCI术后血清CD40-L及IL-8的表达水平,能抑制PCI术后炎性反应,对于急性冠脉综合征有一定疗效。

Influence of tradition Chinese drug for detoxicating and activating blood circulation on expressions of CD40L and IL-8 in patients with acute coronary syndrome after PCI

Objective:To observe influence of traditional Chinese drug(TCD) for detoxicating and activating blood circulation on expressions of CD40L and interleukin(IL)-8 in patients with acute coronary syndrome(ACS) after percutaneous coronary intervention(PCI).Methods:A total of 50 ACS patients after PCI were randomly divided into routine western medicine treatment group(routine treatment group,n=25) and TCD treatment group(n=25,received TCD treatment for detoxicating and activating blood circulation based on routine treatment).Expression levels of CD40L and IL-8 in serum were measured in the two groups before and after treatment.Results:Compared with routine treatment group,there were significant decrease in expression levels of CD40L (1.60±0.62) ng/ml vs.(1.35±0.49) ng/ml]and IL-8 (6.03±0.69) ng/ml vs.(5.33±0.62) ng/ml]in TCD treatment group after treatment,P<0.05 both.Clinical efficacy in TCD treatment group was significantly better than that of routine treatment group(total effective rate:92% vs.72%,P<0.05).Conclusion:Traditional Chinese drug for detoxification and activating blood circulation can significantly decrease serum expression levels of CD40L and IL-8 in ACS patients after PCI,suggesting it can inhibit inflammatory reactions after PCI and possesses certainly effect.