Linkage of X-linked nephrogenic diabetes insipidus with DXS52, a polymorphic DNA marker |
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| Authors: | N Knoers H vd Heyden B A von Oost L Monnens J Willems H H Ropers |
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| Affiliation: | Department of Human Genetics, Catholic University, Nijmegen, The Netherlands. |
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| Abstract: | In five families with X-linked nephrogenic diabetes insipidus (NDI), linkage studies with the DNA marker DXS52, defined by probe St14, have shown no recombination with a maximum combined lod score of 6.40. These results assign the NDI gene to the subtelomeric region of the X chromosome long arm. This finding should facilitate identification of carriers and should also be helpful in finding the NDI gene itself. |
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