| 国产RU486的遗传毒理学评价 |
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| 引用本文： | 王声本,丁亦诺,卢琦华. 国产RU486的遗传毒理学评价[J]. 中国临床药学杂志, 1995, 0(4) |
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| 作者姓名： | 王声本 丁亦诺 卢琦华 |
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| 作者单位： | 上海医科大学 200032(王声本)，上海市计划生育科学研究所 200032(丁亦诺)，上海市计划生育科学研究所 200032(卢琦华) |
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| 基金项目： | 国家《七·五》攻关项目 |
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| 摘 要： | RU486是一种新型抗孕激素催经止孕药。本文对其进行Ames、染色体畸变及微粒等三项体内外遗传毒性试验。结果Ames及染色体畸变试验无论代谢活化与否,RU486均呈阴性反应;微核试验中,即使RU486用量为1.2g╱kg 24h后(临床用量的400倍)亦不引起小鼠骨髓多染微核率增加。提示RU486无遗传毒性作用。
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| 关 键 词： | RU486 致突变作用 Ames试验 染色体畸变 微核 |
GENETICTOXICOLOGICAL EVALUATION ON HOME-MADE RU486 |
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| WANG Sheng-ben. GENETICTOXICOLOGICAL EVALUATION ON HOME-MADE RU486[J]. Chinese Journal of Clinical Pharmacy, 1995, 0(4) |
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| Authors: | WANG Sheng-ben |
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| Affiliation: | WANG Sheng-ben (Shanghai Medical University 200032)DING Yi-nuo LU Qi-hua (Shanghai Institute of Planned Parenthood Research 200032) |
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| Abstract: | RU486 is a steroid analogue with high affinity for progesterone and glucocorli-coid receptors. Test result showed that Home-made RU486 produced no mutagenic effects all in the Ames test and in the chromosome aberration assay with or without metabolic activation. In the micronucleous test,home-made RU486 did not increase the incidence of micronu-cleated polychromatic erythrocytes in the marrow of mice after 24 hours of oral treatment with 1. 2g/kg. |
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| Keywords: | RU486 mutagenicity Ames test Chromosome aberration micronucle-ous test |
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