血栓通注射液治疗不稳定型心绞痛的临床观察

目的:探讨血栓通注射液(有效成分为三七总皂甙)治疗不稳定型心绞痛的疗效。方法:48例不稳定型心绞痛(UAP)患者被随机分为血栓通注射液治疗组(A组)和常规治疗组(B组),两组均进行UAP的常规治疗,A组加用血栓通注射液静脉滴注,治疗2周。观察两组临床疗效,以及治疗前后血浆中纤溶酶原激活物(tPA)及抑制物(PAI)、可溶性细胞间粘附分子-1(SICAM-1)、C-反应蛋白(CRP)水平的变化。结果:①A组的临床疗效显著高于B组(P<0.05);②治疗后A组tPA水平明显升高,PAI水平明显降低(P均<0.01),而B组tPA、PAI治疗前、后无明显的变化;③两组的SICAM-1、CRP水平治疗后明显降低(P<0.01),A组降低的幅度较B组更显著(P均<0.01)。结论:血栓通注射液治疗UAP疗效肯定,且可以改善纤溶活性及减轻炎症反应。

Clinical effect of Xueshuantong injection on unstable angina pectoris

Objective:To study the clinical effect of Xueshuantong injection on unstable angina pectoris.Methods:Forty-eight cases of unstable angina pectoris were randomly and averagely divided into xueshuantong injection treatment group(group A)and routine treatment group(group B).The levels of plasminogen activator inhibitor(PAI),soluble intercellular adhesion molecule-1(SICAM-1)and C-reactive protein(CRP)after two weeks treatment in two groups were observed.Results:The total effective rate was significantly higher in xueshuantong injection treatment group than that in control group(P<0.05).The tPA level significantly increased and the PAI level decreased(P<0.01 all)after treatment in group A,but tPA and PAI no significantly change(P>0.05).Levels of SICAM-1,CRP all decreased(P<0.01)in two groups,but the decrease degree of SICAM and CRP of group A was more than those of group B(P<0.01 all).Conclusion:Xueshuantong injection is an effective drug for UAP,and it may obviously improves fibrinolytic activity and relieves inflammatory reaction.