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Clinical application of 99mTc-HYNIC-TOC SPECT/CT in diagnosing and monitoring of pancreatic neuroendocrine neoplasms
Authors:Junyan Xu  Yingjian Zhang  Dan Huang
Affiliation:1.Department of Nuclear Medicine,Fudan University Shanghai Cancer Center,Shanghai,China;2.Center for Biomedical Imaging,Fudan University,Shanghai,China;3.Shanghai Engineering Research Center of Molecular Imaging Probes,Fudan University,Shanghai,China;4.Department of Oncology, Shanghai Medical College,Fudan University,Shanghai,China;5.Key Laboratory of Nuclear Physics and Ion-beam Application (MOE),Fudan University,Shanghai,China;6.Department of Nuclear Medicine,Shanghai Proton and Heavy Ion Center,Shanghai,China;7.Department of Pancreatic Surgery,Fudan University Shanghai Cancer Center,Shanghai,China;8.Department of Pathology,Fudan University Shanghai Cancer Center,Shanghai,China
Abstract:

Objective

Our aim of this research was to determine the value of SPECT/CT with 99mTc-HYNIC-TOC for evaluation of the pancreatic masses which were suspected as neuroendocrine neoplasms and follow-up of patients with pancreatic neuroendocrine neoplasms.

Methods

We retrospectively analyzed 184 patients who performed 99mTc-HYNIC-TOC SPECT/CT. All the patients were divided into two groups: one for assessment of diagnostic efficiency for pancreatic suspected masses (n?=?140) and another for monitoring recurrence after surgery (n?=?44). The image findings acquired at 2 h postinjection were compared to final diagnoses from pathological results and clinical follow-up. Then, the correlation between ratios of tumor-to-background (TBR) and tumor grade was analyzed.

Results

In group 1, 95/140 (67.9%) patients were confirmed as neuroendocrine neoplasms including 85 neuroendocrine tumors and 10 neuroendocrine carcinomas. Patient-based analysis showed that the sensitivity, specificity and accuracy of diagnosing neuroendocrine neoplasms with SPECT/CT were 81.1, 84.4 and 82.1%. There was significant difference of TBRs among G1, G2 and G3 (F?=?3.175, P?=?0.048). In group 2, 22/44 (50.0%) patients occurred metastasis mainly in liver. The sensitivity, specificity and accuracy of monitoring recurrence were 87.0, 100 and 93.2%.

Conclusions

99mTc-HYNIC-TOC SPECT/CT is a reliable method of diagnosing and monitoring of pancreatic neuroendocrine neoplasms, especially neuroendocrine tumors.
Keywords:
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