| Affiliation: | 1.Biological Systems Sciences Program, Graduate School of Comprehensive Scientific Research,Prefectural University of Hiroshima,Mihara,Japan;2.Department of Radiology,Shimane University Hospital,Izumo,Japan;3.Department of Radiology,Kawasaki Medical School General Medical Center,Okayama,Japan;4.Department of Radiology,Shimane University Faculty of Medicine,Izumo,Japan;5.Department of Neurology,Shimane University Faculty of Medicine,Izumo,Japan |
| Abstract: | PurposeWe evaluated the effect of resolution recovery (RR) using graph plots on regional cerebral blood flow (rCBF) in brain perfusion single-photon emission computed tomography (SPECT) images derived from healthy volunteers and patients diagnosed with probable Alzheimer’s disease.MethodWe acquired brain perfusion SPECT images with scatter correction (SC), computed tomography-based attenuation correction (CTAC), and RR from a three-dimensional brain phantom and from healthy volunteers. We then compared contrast-to-noise ratio, count density ratios, increase maps, and rCBF using statistical parametric mapping 8.ResultsRegional brain counts were significantly increased from 20–24% with SC, CTAC, and RR compared with SC and CTAC. Mean CBF in healthy volunteers was 42.5 ± 5.4 mL/100 g/min. Average rCBF determined using SC, CTAC and RR increased 7.5, 2.0, and 3.7% at the thalamus, posterior cingulate, and whole brain, respectively, compared with SC and CTAC.ConclusionResolution recovery caused variations in normal rCBF because counts increased in cerebral regions. |
