Atypical inflammation in the central nervous system in prion disease |
| |
Authors: | Perry V Hugh Cunningham Colm Boche Delphine |
| |
Affiliation: | CNS Inflammation Group, School of Biological Sciences, University of Southampton, Southampton SO16 7PX, UK. vhp@soton.ac.uk |
| |
Abstract: | The inflammatory response in prion diseases is dominated by microglial activation. Contrary to their profile in vitro none of the pro-inflammatory cytokines interleukin-1beta, interleukin-6, or tumour necrosis factor-alpha are significantly upregulated in the ME7 model of prion disease. However, two major inflammatory mediators are elevated: transforming growth factor-beta1 and prostaglandin E2. This cytokine profile is the same as that reported for macrophages during phagocytosis of apoptotic cells and indeed transforming growth factor-beta1 and prostaglandin E2 are responsible for the downregulated phenotype of these macrophages. Transforming growth factor-beta1 may also have roles in extracellular matrix deposition and in amyloidogenesis and may play a direct role in disease pathogenesis. There is also now evidence to suggest that a peripheral infection, and its consequent systemic cytokine expression, may drive central nervous system cytokine expression and perhaps exacerbate disease. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|