| TIPE1在皮肤鳞状细胞癌中的表达及意义 |
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| 引用本文： | 杨珮雯1,郑 焱1,杨 皎2,李昌吉1,王 敏1,樊文昕1,张 秀1. TIPE1在皮肤鳞状细胞癌中的表达及意义[J]. 现代肿瘤医学, 2018, 0(18): 2945-2947. DOI: 10.3969/j.issn.1672-4992.2018.18.029 |
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| 作者姓名： | 杨珮雯1 郑 焱1 杨 皎2 李昌吉1 王 敏1 樊文昕1 张 秀1 |
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| 作者单位： | 1.西安交通大学第二附属医院皮肤科，陕西 西安 710004；2.西安市第三医院皮肤科，陕西 西安 710018 |
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| 基金项目： | National Natural Science Foundation of China（No.81573055)；国家自然科学基金资助项目(编号:81573055) |
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| 摘 要： | 目的:研究TIPE1在皮肤鳞状细胞癌中的表达变化情况。方法:采用免疫组化方法检测31例皮肤鳞状细胞癌组织和31例正常皮肤组织中TIPE1的表达情况。结果:在正常皮肤组织中，TIPE1弱表达于表皮基底层及棘层下部，在表皮全层表达的阳性率为23.20%。在皮肤鳞状细胞癌中，可见TIPE1高表达于大部分的癌细胞中，阳性率为77.41%。TIPE1在皮肤鳞状细胞癌中的表达显著高于正常皮肤组织(P＜0.05)。结论:TIPE1可能参与皮肤鳞状细胞癌的发生和发展。
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| 关 键 词： | TIPE1 皮肤鳞状细胞癌 皮肤 |
The expression and significance of TIPE1 in skin squamous-cell carcinoma |
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| Yang Peiwen1,Zheng Yan1,Yang Jiao2,Li Changji1,Wang Min1,Fan Wenxin1,Zhang Xiu1. The expression and significance of TIPE1 in skin squamous-cell carcinoma[J]. Journal of Modern Oncology, 2018, 0(18): 2945-2947. DOI: 10.3969/j.issn.1672-4992.2018.18.029 |
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| Authors: | Yang Peiwen1 Zheng Yan1 Yang Jiao2 Li Changji1 Wang Min1 Fan Wenxin1 Zhang Xiu1 |
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| Affiliation: | 1.Department of Dermatology，the Second Affiliated Hospital of Xi＇an Jiaotong University，Shaanxi Xi＇an 710004，China；2.Department of Dermatology，Xi＇an No.3 Hospital，Shaanxi Xi＇an 710018，China. |
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| Abstract: | Objective:To investigate the expression and significance of TIPE1 in the skin squamous-cell carcinoma(SCC)．Methods:Immunohistochemistry was carried out to examine the expression of TIPE1 in tissue specimens from the lesions of 31 patients with SCC，as well as from the skin of 31 normal human controls．Results:In normal skin tissues，TIPE1 was weakly expressed in the basal layer and the lower layers of stratum spinosum of the epidermis，and the positive rate was 23.20% in the whole epidermis.In SCC，TIPE1 was highly expressed in most of the tumor cells and in the whole epidermis the positive rate was 77.41%．The expression of TIPE1 in SCC was significantly higher than that of normal skin (P＜0.05)．Conclusion:The expression of TIPE1 in SCC was significantly higher than that of normal skin and TIPE1 may be involved in the occurrence and development of SCC． |
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| Keywords: | TIPE1 skin squamous-cell carcinoma skin |
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