| Gas6与2型糖尿病及其并发症的研究进展 |
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| 引用本文： | 董雪娥,李会芳. Gas6与2型糖尿病及其并发症的研究进展[J]. 昆明医科大学学报, 2018, 39(3): 119-124 |
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| 作者姓名： | 董雪娥 李会芳 |
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| 作者单位： | 昆明医科大学第一附属医院糖尿病科 |
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| 基金项目： | 基金: 国家自然科学基金资助项目 (81160104, 30760087); 云南省卫生科技计划项目 (2017NS049); |
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| 摘 要： | 生长停滞特异性蛋白6 (growth arrest-specific 6, Gas6) 是维生素K依赖蛋白家族成员, 属于受体酪氨酸激酶家族TAM (Tyro3, Axl, Mer) 的配体.Gas6/Axl信号途径参与细胞的黏附、迁移、增殖、凋亡、血小板聚集, 血管重塑、炎症及免疫反应等病理生理过程.近年来, 研究发现Gas6/Axl信号通路、Gas6水平及其基因多态性与2型糖尿病、肥胖、胰岛素抵抗和糖尿病并发症显著相关.就Gas6与2型糖尿病及其并发症的相关性作一综述.
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| 关 键 词： | Gas6 2型糖尿病 肥胖 胰岛素抵抗 并发症 |
| 收稿时间： | 2017-08-19 |
Research Progress of Gas6 with Type 2Diabetes Mellitus and Diabetic Complications |
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| Abstract: | Growth arrest-specific 6, which is a member of the vitamin K-dependent protein family, is a ligand of TAM (Tyro3, Axl, Mer) belonging to the receptor tyrosine kinase family.Gas6/Axl signaling pathways are involved in pathophysiological processes of cell adhesion, migration, proliferation, apoptosis, platelet aggregation, vascular remodeling, inflammatory and immune responses. In recent years, studies found that Gas6/Axl signaling pathway, Gas6 level and the gene polymorphism of Gas6 were significantly associated with type 2 diabetes, obesity, insulin resistance and diabetic complications.This article reviews the correlation between Gas6 and type 2 diabetes and its complications |
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