大黄提取物治疗伴糖尿病重度牙周炎的疗效观察

目的: 观察大黄提取物局部应用治疗伴糖尿病重度牙周炎的临床疗效。方法: 将50例伴糖尿病的重度牙周炎患者随机分为对照组（龈下刮治和根面平整术）和实验组（龈下刮治和根面平整术+术后局部应用大黄提取物软膏）。2组患者均在治疗前、治疗后6周、治疗后12周检查牙周探诊深度(probing pocket depth, PD)、临床附着水平(clinical attachment level, CAL)、探诊出血指数(bleeding on probing, BOP)。采用SPSS 20.0软件包对实验数据进行统计学分析。结果: 相比治疗前,2组患者在治疗后6周和治疗后12周, PD、CAL、BOP均有下降,实验组低于对照组,有统计学差异。表明2组患者经过治疗后牙周状况都有明显改善,实验组改善优于对照组。整个实验过程中未发生药物不良反应。结论: 大黄提取物局部应用辅助治疗伴糖尿病的重度牙周炎有良好的临床疗效。

The curative effect of rhubarb extract on severe periodontitis in patients with diabetes mellitus

PURPOSE: To observe the curative effect of rhubarb extract on severe periodontitis in patients with diabetes mellitus. METHODS: Fifty patients with severe periodontitis and diabetes mellitus were randomly divided into 2 groups. The patients in the control group were treated with scaling and root planning(SRP); while patients in the experimental group were treated with SRP followed by topical use of rhubarb extract. Periodontal index probing pocket depth (PD), clinical attachment level (CAL) and bleeding on probing (BOP) were examined before periodontal treatment,6 weeks and 12 weeks after treatment. SPSS 20.0 software package was used for statistical analysis. RESULTS: Significant improvement in periodontal condition was noted in both groups after treatment, and the degree of improvement was greater in the experimental group than in the control group. No adverse event during the entire study was found. CONCLUSIONS: Topical application of rhubarb extract for the treatment of severe periodontitis with diabetes has good clinical efficacy.