卵巢硬化性间质瘤10例临床病理分析

目的 探讨卵巢硬化性间质瘤（sclerosing  stromal  tumor of ovary，SST ）的临床病理学特点、诊断、鉴别诊断及预后。方法 回顾性分析10例卵巢硬化性间质瘤的临床表现，观察其组织病理学及免疫表型特征，收集随访资料并复习有关文献。结果 10例SST患者平均年龄48.7岁，主要临床表现为下腹胀痛、月经缩短、绝经后阴道出血、尿频。肿瘤均为单侧发病，表面光滑，带包膜，切面囊实性，灰黄灰白相间。低倍镜下可见典型假小叶结构。免疫表型：肿瘤细胞表达SMA、Vimentin、α-inhibin。结论 卵巢硬化性间质瘤较少见，影像学检查无明显特异性，主要依靠常规病理学诊断，应注意与恶性卵巢肿瘤鉴别。治疗推荐手术切除，效果较好。

Clinical pathological analysis of 10 cases of ovarian sclerosingstromal tumor

Objective To analyze the clinicopathological characteristics and differential diagnosis of ovarian sclerosing stromal tumor.Methods The clinicopathological characteristics of 10 cases of ovarian sclerosing  stromal tumor treated at our hospital were examined. Results Mean age of the patients was 48.7 years（17-78  years） and clinical symptoms were usually abdominal pain，shortened menstruation，postmenopausal bleeding and frequent micturition. Macroexamination revealed unilateral，glossy and coated tumors with a surface cap-sule. Optical microscopy of tumor tissue revealed a false lobular structure. All patients were positive for SMA，Vimentin，and α-inhibin. Conclusions Ovarian sclerosing stromal tumor is rare and clinical data about the disease are limited. Therefore diagnosis is difficult and usually relies on pathology and the efficacy of operation is good.